S100B Monoclonal / Janelia Fluor 646 / SPM354

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-54399JF646 (View supplier product page)
Size 0.1 ml
Price $529.00
Antigen S100B
Clone SPM354
Host Mouse
Isotype IgG2a κ
Conjugate Janelia Fluor 646
Target Species Bovine, Human, Mouse, Rat
Applications FC, IHC, ICC/IF, IHC-P
Description Mouse S100B antibody [Janelia Fluor 646] detects Human, Mouse, Rat, Bovine
About S100B and Janelia Fluor 646
S100B The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra