Respiratory Syncytial Virus glycoprotein F Monoclonal / DyLight 405 / 11-2-F3

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-50412V (View supplier product page)
Size 0.1 ml
Price $449.00
Antigen Respiratory Syncytial Virus glycoprotein F
Clone 11-2-F3
Host Mouse
Isotype IgG1
Conjugate DyLight 405
Target Species Virus
Applications WB, ELISA
Description This antibody reacts with the RS virus fusion glycoprotein F (also named VP70 or F0 protein), specifically to a subunit of the F protein, F1 (also named VGP48 or 48kDa), from both subgroups A and B of RS virus.This antibody has a high neutralising activity; 90% plaque neutralization titre of 102.2 (Gimenez et al 1996). This property makes it potentially useful for the preparation of reagents for prevention and/or therapeutic use (for example, vaccines or new-generation of man-made antibodies). The characterisation of the epitope of this antibody which induce high neutralising activity will be useful for the preparation of reagents (for example vaccine) to prevent RS virus infection. A RS virus vaccine is not yet available. A vaccine could be used to increase the maternal immunity to RS virus, which would then be passed to the newborn baby to provide passive immunity.The further characterisation of the epitope recognised by this antibody, which possesses a high neutralising activity, will be useful for the preparation of reagents to prevent RS virus infection. New-generation man-made antibodies, based on the 11-2-F3 antibody, could complement the effectiveness of polivizumab (Synagis), which is used to prevent but not treat established RS virus infections (Nature Biotechnology, 2013, 31, 952).
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DyLight 405 Excitation and Emission Spectra