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	Supplier	Miltenyi Biotec
	Catalog #:	130-115-927 (View supplier product page)
	Size	30 µg in 200 µL
	Price	$65.00
	Antigen	CD180
	Clone	REA957
	Host	Human
	Isotype	IgG1
	Conjugate	Biotin
	Target Species	Mouse
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA957 recognizes the mouse CD180 antigen, also known as RP105, a type I transmembrane protein structurally similar to toll-like receptors (TLRs) with the conserved features of TLRs, including a leucine-rich repeat extracellular domain and regions containing conserved cysteines. However, in contrast to TLRs, CD180 lacks a typical TIR domain, containing only 6–11 intracytoplasmic amino acids. Antibody mediated ligation of CD180 was shown to induce B cell proliferation and protection from subsequent radiation- or dexamethasone-induced apoptosis. Expression of CD180 is found on mature B cells, monocytes, macrophages, and dendritic cells. CD180 activity is dependent on physical association with a molecule called MD-1. In B cells, CD180, together with TLR4, has been shown to induce B cell proliferation in response to LPS. However, in primary myeloid cells and in vivo, CD180 acts as an inhibitor of TLR4 signaling. \| Additional information: Clone REA957 displays negligible binding to Fc receptors.

	CD180	CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

$65.00
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CD180 Monoclonal / Biotin / REA957