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	Supplier	Miltenyi Biotec
	Catalog #:	130-115-918 (View supplier product page)
	Size	30 tests in 60 µL
	Price	$95.00
	Antigen	CD180
	Clone	REA956
	Host	Human
	Isotype	IgG1
	Conjugate	Biotin
	Target Species	Human
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA956 recognizes the human CD180 antigen, also known as RP105, which is a 105 kDa type 1 transmembrane protein of the toll-like receptor (TLR) family. The extracellular domain of CD180 is associated with MD-1, which forms the cell surface complex RP105/MD-1. Together with TLR4, it mediates B cell recognition and signaling of LPS. RP105 is expressed on mature B cells in mantle zones as well as on monocytes, macrophages, and dendritic cells. \| Additional information: Clone REA956 displays negligible binding to Fc receptors.

	CD180	CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

$95.00
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CD180 Monoclonal / Biotin / REA956