F4/80 RealYellow 655 (T45-2342, Rat) - Reactivity: Mouse
Product Details
| Description |
The T45-2342 monoclonal antibody recognizes the mouse F4/80 antigen which is also known as EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1). F4/80 is a 160 kDa glycoprotein that belongs to the EGF-TM7 family of seven-transmembrane spanning cell surface molecules. It is expressed on the surface of granulocytes and a wide range of mature tissue macrophages including, Kupffer cells, splenic red pulp macrophages, microglia, gut lamina propria macrophages, and Langerhans cells. F4/80 expression has also been reported on subpopulations of dendritic cells. F4/80 expression is heterogeneous and may be increased during inflammatory responses as observed in various mouse models of colitis, diabetes and brain injury. |
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| Conjugate | RealYellow 655 | |
| Clone | T45-2342 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | BD Biosciences | |
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About F4/80
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
About RealYellow 655
BD Horizon RealYellow 655 (RY655) has an excitation peak at 557 nm and an emission peak at 654 nm. RY655 reagents offer a bright fluorochrome to support the detection of low expression surface and intracellular markers and increase panel design flexibility, offering minimal cross-laser excitation from the 488-nm blue laser in hundreds of antibody specificities.. RY655 is excited primarily by the 561 nm yellow-green laser.
BD Horizon RealYellow 655 (RY655) has an excitation peak at 557 nm and an emission peak at 654 nm. RY655 reagents offer a bright fluorochrome to support the detection of low expression surface and intracellular markers and increase panel design flexibility, offering minimal cross-laser excitation from the 488-nm blue laser in hundreds of antibody specificities.. RY655 is excited primarily by the 561 nm yellow-green laser.
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